UPB
Upstream Bio, Inc.
NASDAQ · Healthcare · Biotechnology · US
$5.34
+0.56%0
Insider buys (3m)
5
Insider sells (3m)
-$27.6K
Net value (3m)
-16.2%
Price return (3m)
Form 4 filings
| Date | Insider | Activity | Shares | Price |
|---|---|---|---|---|
| Sep 17, 2026 | GRAY MICHAEL · officer: CFO and COO | Sale | 853 | $5.49 |
| Sep 17, 2026 | Sutherland Everett Rand · director, officer: Chief Executive Officer | Sale | 2,095 | $5.49 |
| Sep 17, 2026 | Houghton Adam · officer: Chief Business Officer | Sale | 700 | $5.49 |
| Sep 17, 2026 | Deykin Aaron · officer: Chief Medical Officer | Sale | 895 | $5.49 |
| Sep 17, 2026 | Ambrose Allison · officer: General Counsel | Sale | 485 | $5.49 |
| Jun 17, 2026 | Houghton Adam · officer: Chief Business Officer | Sale | 700 | $6.10 |
| Jun 17, 2026 | Ambrose Allison · officer: General Counsel | Sale | 477 | $6.10 |
| Jun 17, 2026 | Deykin Aaron · officer: Chief Medical Officer | Sale | 895 | $6.10 |
| Jun 17, 2026 | Sutherland Everett Rand · director, officer: Chief Executive Officer | Sale | 2,095 | $6.10 |
| Jun 17, 2026 | GRAY MICHAEL · officer: CFO and COO | Sale | 853 | $6.10 |
| Jun 11, 2026 | Renaud Ronald C JR · director | A-Award | 17,096 | $6.69 |
| Jun 11, 2026 | Chimovits Erez · director | A-Award | 17,096 | $6.69 |
| Jun 11, 2026 | Ratcliffe Liam · director | A-Award | 17,096 | $6.69 |
| Jun 11, 2026 | Beckman Daniella · director | A-Award | 17,096 | $6.69 |
| Jun 11, 2026 | Ruddy Marcella K. · director | A-Award | 17,096 | $6.69 |
| Jun 11, 2026 | Fleming Harold Edward · director | A-Award | 17,096 | $6.69 |
| Mar 17, 2026 | Sutherland Everett Rand · director, officer: Chief Executive Officer | Sale | 2,093 | $9.29 |
| Mar 17, 2026 | GRAY MICHAEL · officer: CFO and COO | Sale | 852 | $9.29 |
| Mar 17, 2026 | Deykin Aaron · officer: Chief Medical Officer | Sale | 894 | $9.29 |
| Mar 17, 2026 | Ambrose Allison · officer: General Counsel | Sale | 475 | $9.29 |
| Mar 17, 2026 | Houghton Adam · officer: Chief Business Officer | Sale | 699 | $9.29 |
| Jan 6, 2026 | GRAY MICHAEL · officer: CFO and COO | A-Award | 30,500 | $0.00 |
| Jan 6, 2026 | Houghton Adam · officer: Chief Business Officer | A-Award | 75,000 | $27 |
| Jan 6, 2026 | Ambrose Allison · officer: General Counsel | A-Award | 17,000 | $0.00 |
| Jan 6, 2026 | Ambrose Allison · officer: General Counsel | A-Award | 51,000 | $27 |
| Jan 6, 2026 | Deykin Aaron · officer: Chief Medical Officer | A-Award | 32,000 | $0.00 |
| Jan 6, 2026 | Deykin Aaron · officer: Chief Medical Officer | A-Award | 96,000 | $27 |
| Jan 6, 2026 | GRAY MICHAEL · officer: CFO and COO | A-Award | 91,500 | $27 |
| Jan 6, 2026 | Sutherland Everett Rand · director, officer: Chief Executive Officer | A-Award | 75,000 | $0.00 |
| Jan 6, 2026 | Sutherland Everett Rand · director, officer: Chief Executive Officer | A-Award | 225,000 | $27 |
Institutional positioning
13F filings over the trailing two quarters
New 84Increased 115Reduced 66Sold out 27
| Filer | Action | Shares | Filed |
|---|---|---|---|
| FMR LLC | Increased | 8,162,897 | Aug 13, 2026 |
| FMR LLC | Increased | 8,101,563 | May 15, 2026 |
| ORBIMED ADVISORS LLC | Unchanged | 5,693,589 | May 15, 2026 |
| ORBIMED ADVISORS LLC | Unchanged | 5,693,589 | Aug 14, 2026 |
| NORGES BANK | New Position | 3,768,619 | Aug 12, 2026 |
| BlackRock, Inc. | Increased | 3,753,358 | Aug 7, 2026 |
| BLACKROCK, INC. | Increased | 3,370,689 | May 13, 2026 |
| Decheng Capital LLC | Unchanged | 2,724,868 | Aug 14, 2026 |
| DECHENG CAPITAL LLC | Reduced | 2,724,868 | May 13, 2026 |
| Enavate Sciences GP, LLC | Unchanged | 2,459,703 | Aug 14, 2026 |
| ENAVATE SCIENCES GP, LLC | Unchanged | 2,459,703 | May 15, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 1,876,734 | Aug 13, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 1,873,574 | May 15, 2026 |
| MILLENNIUM MANAGEMENT LLC | Increased | 1,143,775 | Aug 14, 2026 |
| D. E. Shaw & Co., Inc. | Increased | 1,036,044 | Aug 14, 2026 |
Insider activity from SEC Form 4; institutional positioning from 13F filings · Latest filing Sep 17, 2026