Upstream Bio, Inc. (UPB) Insider Trading
Over the last 3 months, UPB insiders made 0 open-market buys and 5 sales, a net sale of -$31K (SEC Form 4). Over the last 6 months, 49 institutions increased and 36 reduced their position (13F).
Insider Activity
Sentiment
0/100
Buys (3m)
0
Sells (3m)
5
Net (3m)
-$30.6K
Insider trades by month Buys Sells
Mar
Jun
Context3-month price -18.1%Institutions reducing (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Jun 17, 2026 | Ambrose Allisonofficer: General Counsel | Sell | 477 | $6.10 |
| Jun 17, 2026 | Deykin Aaronofficer: Chief Medical Officer | Sell | 895 | $6.10 |
| Jun 17, 2026 | Houghton Adamofficer: Chief Business Officer | Sell | 700 | $6.10 |
| Jun 17, 2026 | Sutherland Everett Randdirector, officer: Chief Executive Officer | Sell | 2,095 | $6.10 |
| Jun 17, 2026 | GRAY MICHAELofficer: CFO and COO | Sell | 853 | $6.10 |
| Jun 11, 2026 | Ruddy Marcella K.director | Grant | 17,096 | $6.69 |
| Jun 11, 2026 | Renaud Ronald C JRdirector | Grant | 17,096 | $6.69 |
| Jun 11, 2026 | Chimovits Erezdirector | Grant | 17,096 | $6.69 |
| Jun 11, 2026 | Ratcliffe Liamdirector | Grant | 17,096 | $6.69 |
| Jun 11, 2026 | Beckman Danielladirector | Grant | 17,096 | $6.69 |
| Jun 11, 2026 | Fleming Harold Edwarddirector | Grant | 17,096 | $6.69 |
| Mar 17, 2026 | GRAY MICHAELofficer: CFO and COO | Sell | 852 | $9.29 |
| Mar 17, 2026 | Deykin Aaronofficer: Chief Medical Officer | Sell | 894 | $9.29 |
| Mar 17, 2026 | Sutherland Everett Randdirector, officer: Chief Executive Officer | Sell | 2,093 | $9.29 |
| Mar 17, 2026 | Ambrose Allisonofficer: General Counsel | Sell | 475 | $9.29 |
| Mar 17, 2026 | Houghton Adamofficer: Chief Business Officer | Sell | 699 | $9.29 |
| Jan 6, 2026 | GRAY MICHAELofficer: CFO and COO | Grant | 91,500 | $27.07 |
| Jan 6, 2026 | Ambrose Allisonofficer: General Counsel | Grant | 51,000 | $27.07 |
| Jan 6, 2026 | Deykin Aaronofficer: Chief Medical Officer | Grant | 32,000 | — |
| Jan 6, 2026 | Deykin Aaronofficer: Chief Medical Officer | Grant | 96,000 | $27.07 |
| Jan 6, 2026 | GRAY MICHAELofficer: CFO and COO | Grant | 30,500 | — |
| Jan 6, 2026 | Sutherland Everett Randdirector, officer: Chief Executive Officer | Grant | 75,000 | — |
| Jan 6, 2026 | Sutherland Everett Randdirector, officer: Chief Executive Officer | Grant | 225,000 | $27.07 |
| Jan 6, 2026 | Houghton Adamofficer: Chief Business Officer | Grant | 25,000 | — |
| Jan 6, 2026 | Houghton Adamofficer: Chief Business Officer | Grant | 75,000 | $27.07 |
| Jan 6, 2026 | Ambrose Allisonofficer: General Counsel | Grant | 17,000 | — |
| Jun 12, 2025 | Fleming Harold Edwarddirector | Grant | 17,096 | $11.59 |
| Jun 12, 2025 | Chimovits Erezdirector | Grant | 17,096 | $11.59 |
| Jun 12, 2025 | Renaud Ronald C JRdirector | Grant | 17,096 | $11.59 |
| Jun 12, 2025 | Ratcliffe Liamdirector | Grant | 17,096 | $11.59 |
Source: UPB SEC Form 4 filings, latest Jun 17, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their UPB positions over the last 6 months (SEC Form 13F).
Increased
49
New positions
47
Reduced
36
Sold out
141
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| FMR LLC | Increased | 8.1M | May 15, 2026 |
| ORBIMED ADVISORS LLC | Unchanged | 5.7M | May 15, 2026 |
| BLACKROCK, INC. | Increased | 3.4M | May 13, 2026 |
| DECHENG CAPITAL LLC | Reduced | 2.7M | May 13, 2026 |
| ENAVATE SCIENCES GP, LLC | Unchanged | 2.5M | May 15, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 1.9M | May 15, 2026 |
| Y-INTERCEPT (HONG KONG) LTD | Increased | 1.0M | Apr 27, 2026 |
| FEDERATED HERMES, INC. | Increased | 980K | May 11, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | 951K | May 15, 2026 |
| MILLENNIUM MANAGEMENT LLC | Increased | 937K | May 15, 2026 |
| SEB Asset Management AB | New Position | 878K | May 7, 2026 |
| BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC | Reduced | 867K | May 15, 2026 |
| WOODLINE PARTNERS LP | Increased | 831K | May 15, 2026 |
| D. E. SHAW & CO., INC. | Increased | 820K | May 15, 2026 |
| PARKMAN HEALTHCARE PARTNERS LLC | Reduced | 787K | May 15, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.