Spyre Therapeutics, Inc. (SYRE) Insider Trading
Over the last 3 months, SYRE insiders made 0 open-market buys and 22 sales, a net sale of -$410.2M (SEC Form 4). Over the last 6 months, 170 institutions increased and 109 reduced their position (13F).
Insider Activity
Sentiment
0/100
Buys (3m)
0
Sells (3m)
22
Net (3m)
-$410.2M
Insider trades by month Buys Sells
Mar
Apr
May
Jun
Jul
Aug
Context3-month price +26.4%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Aug 10, 2026 | Albers Jeffrey W.director | Sell | 10,000 | $104.68 |
| Aug 10, 2026 | Albers Jeffrey W.director | Sell | 8,000 | $104.38 |
| Aug 10, 2026 | Albers Jeffrey W.director | Sell | 5,000 | $104.47 |
| Aug 10, 2026 | Albers Jeffrey W.director | Option | 5,000 | $10.39 |
| Aug 5, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 7,157 | $95.10 |
| Aug 5, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 800 | $93.97 |
| Aug 5, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 100 | $97.10 |
| Aug 5, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 2,300 | $96.30 |
| Aug 5, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 7,500 | $14.50 |
| Aug 5, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 5,100 | $95.21 |
| Aug 5, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 16 | $97.46 |
| Aug 5, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 1,392 | $96.82 |
| Aug 5, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 5,635 | $95.93 |
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 5,775 | $87.55 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 590 | $88.91 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 4,234 | $88.12 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 10,176 | $87.44 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Sell | 1,834 | $88.34 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Sell | 6,500 | $87.52 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Option | 8,334 | $27.46 |
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 1,725 | $88.37 |
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 7,500 | $14.50 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 10,000 | $87.14 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 5,000 | $87.12 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 15,000 | $14.50 |
| Jun 23, 2026 | HENDERSON MICHAEL THOMASdirector | Sell | 20,000 | $100.00 |
| Jun 23, 2026 | Fairmount Funds Management LLCdirector | Sell | 4,684,781 | $85.31 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 2,599 | $70.77 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 1,801 | $69.75 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 7,500 | $14.50 |
Source: SYRE SEC Form 4 filings, latest Aug 10, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their SYRE positions over the last 6 months (SEC Form 13F).
Increased
170
New positions
148
Reduced
109
Sold out
21
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| FMR LLC | Increased | 13.0M | Aug 13, 2026 |
| FMR LLC | Increased | 11.8M | May 15, 2026 |
| BlackRock, Inc. | Increased | 6.5M | Aug 7, 2026 |
| BLACKROCK, INC. | Reduced | 5.5M | May 13, 2026 |
| PERCEPTIVE ADVISORS LLC | Increased | 4.3M | Aug 14, 2026 |
| RTW INVESTMENTS, LP | Increased | 4.3M | Aug 14, 2026 |
| RTW INVESTMENTS, LP | Unchanged | 4.2M | May 15, 2026 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unchanged | 4.0M | May 15, 2026 |
| Paradigm Biocapital Advisors LP | Increased | 3.8M | Aug 14, 2026 |
| PERCEPTIVE ADVISORS LLC | Increased | 3.8M | May 29, 2026 |
| VR ADVISER, LLC | Unchanged | 3.7M | May 15, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 3.4M | Aug 13, 2026 |
| STATE STREET CORP | Increased | 3.1M | Aug 7, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 3.1M | May 15, 2026 |
| VR Adviser, LLC | Reduced | 3.0M | Aug 14, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.