Spyre Therapeutics, Inc. (SYRE) Insider Trading

Over the last 3 months, SYRE insiders made 0 open-market buys and 34 sales, a net sale of -$420.2M (SEC Form 4). Over the last 6 months, 146 institutions increased and 79 reduced their position (13F).

Insider Activity

Sentiment
0/100
Buys (3m)
0
Sells (3m)
34
Net (3m)
-$420.2M
Insider trades by month Buys Sells
Jan
Feb
Mar
Apr
May
Jun
Context3-month price +76%Institutions accumulating (13F)
DateInsiderTypeSharesPrice
Jun 26, 2026Burrows Scott Lofficer: Chief Financial OfficerSell10,000$87.14
Jun 26, 2026Burrows Scott Lofficer: Chief Financial OfficerSell5,000$87.12
Jun 26, 2026Burrows Scott Lofficer: Chief Financial OfficerOption15,000$14.50
Jun 23, 2026HENDERSON MICHAEL THOMASdirectorSell20,000$100.00
Jun 23, 2026Fairmount Funds Management LLCdirectorSell4,684,781$85.31
Jun 3, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell3,294$71.38
Jun 3, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell8,149$70.50
Jun 3, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell3,557$69.40
Jun 3, 2026Sloan Sheldonofficer: Chief Medical OfficerOption8,333$27.46
Jun 3, 2026Sloan Sheldonofficer: Chief Medical OfficerSell8,333$75.00
Jun 3, 2026Burrows Scott Lofficer: Chief Financial OfficerSell3,100$72.06
Jun 3, 2026Burrows Scott Lofficer: Chief Financial OfficerSell2,599$70.77
Jun 3, 2026Burrows Scott Lofficer: Chief Financial OfficerSell1,801$69.75
Jun 3, 2026Burrows Scott Lofficer: Chief Financial OfficerOption7,500$14.50
May 29, 2026Albers Jeffrey W.directorGrant8,026$72.51
May 29, 2026Milligan SandradirectorGrant8,026$72.51
May 29, 2026McKenna Mark C.directorGrant8,026$72.51
May 29, 2026Stelzer LauriedirectorGrant8,026$72.51
May 29, 2026HENDERSON MICHAEL THOMASdirectorGrant8,026$72.51
May 29, 2026Fairmount Funds Management LLCdirectorGrant8,026$72.51
May 8, 2026HENDERSON MICHAEL THOMASdirectorSell33,513$73.72
May 8, 2026HENDERSON MICHAEL THOMASdirectorSell19,269$75.35
May 8, 2026HENDERSON MICHAEL THOMASdirectorSell24,814$74.76
May 8, 2026HENDERSON MICHAEL THOMASdirectorSell2,404$72.57
May 1, 2026Burrows Scott Lofficer: Chief Financial OfficerSell12,500$71.37
May 1, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell300$74.96
May 1, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell1,700$74.23
May 1, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell3,100$73.14
May 1, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell1,000$71.76
May 1, 2026Turtle Camerondirector, officer: Chief Executive OfficerSell3,600$70.77

Source: SYRE SEC Form 4 filings, latest Jun 26, 2026. For informational purposes only — not investment advice.

Institutional activity (13F)

How institutions changed their SYRE positions over the last 6 months (SEC Form 13F).

Increased
146
New positions
87
Reduced
79
Sold out
27
Largest moves
InstitutionActionSharesFiled
FMR LLCIncreased11.8MMay 15, 2026
FMR LLCIncreased11.6MFeb 17, 2026
PERCEPTIVE ADVISORS LLCIncreased7.6MMay 29, 2026
VANGUARD CAPITAL MANAGEMENT LLCNew Position6.1MMay 15, 2026
BLACKROCK, INC.Increased5.5MFeb 12, 2026
BLACKROCK, INC.Reduced5.5MMay 13, 2026
RTW INVESTMENTS, LPUnchanged4.2MMay 15, 2026
RTW INVESTMENTS, LPIncreased4.2MFeb 17, 2026
VANGUARD GROUP INCIncreased4.0MJan 29, 2026
FAIRMOUNT FUNDS MANAGEMENT LLCUnchanged4.0MFeb 17, 2026
FAIRMOUNT FUNDS MANAGEMENT LLCUnchanged4.0MMay 15, 2026
VR ADVISER, LLCIncreased3.7MFeb 17, 2026
VR ADVISER, LLCUnchanged3.7MMay 15, 2026
CAPITAL INTERNATIONAL INVESTORSIncreased3.5MFeb 11, 2026
Remedium Capital Partners, LLCIncreased3.4MMay 19, 2026

Source: SEC Form 13F filings. For informational purposes only — not investment advice.

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