Septerna, Inc. (SEPN) Insider Trading
Over the last 3 months, SEPN insiders made 0 open-market buys and 13 sales, a net sale of -$41.4M (SEC Form 4). Over the last 6 months, 94 institutions increased and 66 reduced their position (13F).
Insider Activity
Sentiment
0/100
Buys (3m)
0
Sells (3m)
13
Net (3m)
-$41.4M
Insider trades by month Buys Sells
Mar
Apr
May
Jun
Jul
Aug
Context3-month price +27.7%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Aug 14, 2026 | Third Rock Ventures V, L.P.10 percent owner | Sell | 147,059 | $50.27 |
| Aug 14, 2026 | RA CAPITAL MANAGEMENT, L.P.director, 10 percent owner: | Sell | 746,500 | $42.50 |
| Aug 14, 2026 | Third Rock Ventures V, L.P.10 percent owner | Sell | 141 | $51.08 |
| Aug 13, 2026 | Bhatt Elizabethofficer: President and COO | Option | 18,681 | $6.81 |
| Aug 13, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 25,000 | $44.00 |
| Aug 13, 2026 | Bhatt Elizabethofficer: President and COO | Option | 6,319 | $2.76 |
| Aug 5, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Option | 1,816 | $2.76 |
| Aug 5, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 2,334 | $34.68 |
| Aug 5, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 1,000 | $33.98 |
| Aug 5, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Option | 1,518 | $2.76 |
| Jul 17, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 4,000 | $33.99 |
| Jul 17, 2026 | Bhatt Elizabethofficer: President and COO | Option | 4,000 | $6.81 |
| Jul 2, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 2,100 | $34.10 |
| Jul 2, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 1,233 | $34.81 |
| Jul 2, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Option | 3,333 | $2.76 |
| Jun 30, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 2,178 | $6.81 |
| Jun 30, 2026 | Simson Jakedirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Ezekowitz Alandirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Gottesdiener Keith Michaeldirector | Grant | 11,260 | $37.34 |
| Jun 30, 2026 | Tong Jeffrey Kdirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Coulie Bernarddirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Sharp Shalinidirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Bassan Abrahamdirector | Grant | 15,000 | $37.34 |
| Jun 30, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 2,178 | $35.18 |
| Jun 30, 2026 | RA CAPITAL MANAGEMENT, L.P.director, 10 percent owner: | Grant | 15,000 | $37.34 |
| Jun 24, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Option | 4,471 | $11.70 |
| Jun 24, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 7,000 | $35.97 |
| Jun 24, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 8,000 | $35.10 |
| Jun 24, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Option | 10,529 | $2.76 |
| Jun 16, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 6,250 | $35.08 |
Source: SEPN SEC Form 4 filings, latest Aug 14, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their SEPN positions over the last 6 months (SEC Form 13F).
Increased
94
New positions
78
Reduced
66
Sold out
15
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Unchanged | 7.0M | May 15, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | Unchanged | 7.0M | Aug 14, 2026 |
| TRV GP V, LLC | Unchanged | 6.2M | May 7, 2026 |
| TRV GP V, LLC | Unchanged | 6.2M | Aug 10, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | Increased | 4.4M | Aug 14, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | Reduced | 4.4M | May 15, 2026 |
| TRV GP VI, LLC | Unchanged | 4.2M | May 7, 2026 |
| TRV GP VI, LLC | Unchanged | 4.2M | Aug 10, 2026 |
| SAMSARA BIOCAPITAL, LLC | Unchanged | 3.1M | May 15, 2026 |
| Samsara BioCapital, LLC | Unchanged | 3.1M | Aug 14, 2026 |
| GOLDMAN SACHS GROUP INC | Increased | 3.1M | Aug 14, 2026 |
| GOLDMAN SACHS GROUP INC | Reduced | 2.9M | May 15, 2026 |
| GOLDMAN SACHS GROUP INC | Increased | 2.7M | Mar 25, 2026 |
| SIREN, L.L.C. | Unchanged | 2.0M | May 14, 2026 |
| BlackRock, Inc. | Increased | 1.9M | Aug 7, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.