Ionis Pharmaceuticals, Inc. (IONS) Insider Trading
Over the last 3 months, IONS insiders made 2 open-market buys and 16 sales, a net sale of -$18.0M (SEC Form 4). Over the last 6 months, 391 institutions increased and 319 reduced their position (13F).
Insider Activity
Sentiment
5/100
Buys (3m)
2
Sells (3m)
16
Net (3m)
-$18.0M
Insiders buying
Insider trades by month Buys Sells
Feb
Mar
Apr
May
Jun
Jul
Context3-month price -20.4%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Jul 31, 2026 | Hayden Michael Rdirector | Buy | 5,000 | $51.60 |
| Jul 31, 2026 | Hayden Michael Rdirector | Buy | 15,000 | $53.38 |
| Jul 17, 2026 | Reikes Peter Ndirector | Grant | 3,399 | — |
| Jul 17, 2026 | HANTSON LUDWIGdirector | Grant | 3,399 | — |
| Jul 17, 2026 | HERMAN JOAN Edirector | Option | 5,220 | — |
| Jul 17, 2026 | BERTHELSEN SPENCER Rdirector | Option | 5,220 | — |
| Jul 9, 2026 | BENNETT C FRANKofficer: EVP, Chief Scientific Officer | Sell | 15,000 | $85.46 |
| Jul 9, 2026 | Diaz Allene M.director | Sell | 10,111 | $85.42 |
| Jul 9, 2026 | BENNETT C FRANKofficer: EVP, Chief Scientific Officer | Sell | 5,536 | $83.58 |
| Jul 9, 2026 | Kordasiewicz Holly B.officer: EVP, Chief Development Officer | Sell | 362 | $84.30 |
| Jul 9, 2026 | Diaz Allene M.director | Option | 10,111 | $47.11 |
| Jul 6, 2026 | HERMAN JOAN Edirector | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | Diaz Allene M.director | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | LOSCALZO JOSEPHdirector | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | KLEIN JOSEPH IIIdirector | Grant | 2,301 | — |
| Jul 6, 2026 | BERTHELSEN SPENCER Rdirector | Grant | 2,301 | — |
| Jul 6, 2026 | Hayden Michael Rdirector | Grant | 2,301 | — |
| Jul 6, 2026 | LOSCALZO JOSEPHdirector | Grant | 2,301 | — |
| Jul 6, 2026 | YANG MICHAEL J.director | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | YANG MICHAEL J.director | Grant | 2,301 | — |
| Jul 6, 2026 | Hayden Michael Rdirector | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | BERTHELSEN SPENCER Rdirector | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | KLEIN JOSEPH IIIdirector | Option | 11,518 | $39.94 |
| Jul 6, 2026 | KLEIN JOSEPH IIIdirector | Sell | 11,419 | $79.04 |
| Jul 6, 2026 | KLEIN JOSEPH IIIdirector | Sell | 99 | $79.45 |
| Jul 6, 2026 | HERMAN JOAN Edirector | Grant | 2,301 | — |
| Jul 6, 2026 | KLEIN JOSEPH IIIdirector | Grant | 5,369 | $79.19 |
| Jul 6, 2026 | Diaz Allene M.director | Grant | 2,301 | — |
| Jun 30, 2026 | Schneider Eugeneofficer: EVP, Chf Clinical Develop Ofcr | Sell | 26,000 | $81.05 |
| Jun 30, 2026 | Baroldi Josephofficer: EVP, Chief Business Officer | Option | 3,866 | $56.78 |
Source: IONS SEC Form 4 filings, latest Jul 31, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their IONS positions over the last 6 months (SEC Form 13F).
Increased
391
New positions
141
Reduced
319
Sold out
44
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| FMR LLC | Increased | 24.6M | Aug 13, 2026 |
| FMR LLC | Increased | 24.6M | May 15, 2026 |
| Capital World Investors | Increased | 21.7M | Aug 12, 2026 |
| CAPITAL WORLD INVESTORS | Increased | 21.2M | May 13, 2026 |
| BlackRock, Inc. | Increased | 10.7M | Aug 7, 2026 |
| BLACKROCK, INC. | Reduced | 10.4M | May 13, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Increased | 7.9M | Aug 13, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | New Position | 7.8M | May 8, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | Increased | 7.7M | Aug 14, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | Increased | 7.2M | Aug 13, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 7.1M | May 15, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | Increased | 6.4M | May 15, 2026 |
| TWO SIGMA INVESTMENTS, LP | Increased | 6.3M | Aug 14, 2026 |
| ROYAL BANK OF CANADA | Increased | 6.2M | Aug 14, 2026 |
| T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | Reduced | 6.2M | May 15, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.